Repurposing Poly(3‐hexylthiophene) as a Conductivity‐Reducing Additive for Polyethylene‐Based High‐Voltage Insulation

Repurposing ARBs as treatments for breast cancer

Ontologies as facilitators for repurposing web documents

This paper investigates the role of ontologies as a central part of an architecture to repurpose existing material from the web. A prototype system called ArtEquAKT is presented, which combines information extraction, knowledge management and consolidation techniques and adaptive document generation. All of these components are co-ordinated using one central ontology, providing a common vocabul...

Use of olive stone as an additive in cement lime mortar to improve thermal insulation

The process of olive oil extraction produces olive stone, a residue which cause considerable problems of disposal. This paper proposes and analyzes an original use of olive stone in order to improve the heat insulation performances of cement lime mortar and reduce its final density. To this purpose, the paper illustrates a set of small-scale tests, which were conducted on specimens of cement li...

Repurposing celecoxib as a topical antimicrobial agent

There is an urgent need for new antibiotics and alternative strategies to combat multidrug-resistant bacterial pathogens, which are a growing clinical issue. Repurposing existing approved drugs with known pharmacology and toxicology is an alternative strategy to accelerate antimicrobial research and development. In this study, we show that celecoxib, a marketed inhibitor of cyclooxygenase-2, ex...

Repurposing itraconazole as an anticancer agent.

Itraconazole, a common anti-fungal agent, has demonstrated potential anticancer activity, including reversing chemoresistance mediated by P-glycoprotein, modulating the signal transduction pathways of Hedgehog, mechanistic target of rapamycin and Wnt/β-catenin in cancer cells, inhibiting angiogenesis and lymphangiogenesis, and possibly interfering with cancer-stromal cell interactions. Clinical...